Statins are increasingly being used for the treatment of a variety of conditions beyond their
original indication for cholesterol lowering. We previously reported that simvastatin
increased dopamine receptors in the rat prefrontal cortex [Q. Wang, WL Ting, H. Yang, PT
Wong, High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in
the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase, Br. J.
Pharmacol. 144 (2005) 933–939] and restored its downregulation in a model of Parkinson's …

"Effects of high dose of simvastatin on levels of dopamine and its reup" by How-Sung Lee,
Qing Wang et al. … Effects of high dose of simvastatin on levels of dopamine and its
reuptake in prefrontal cortex and striatum among SD rats … Effects of high dose of
simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among
SD rats. Neuroscience Letters, 408 (3), 189-193. …